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apalutamide will lower the extent or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medicine which might be CYP3A4 substrates may result in reduce exposure to those medications.Belzutifan is really a CYP2C19 substrate.